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自从发现小白鼠足垫能使麻风杆菌生长以来,在临床应用上,出现了过分强调实验室结果的情况,并由此在麻风领城内曾经导致某些悲惨的后果。有两个著名的例子值得引证,它是基于以下两个论点的:(1)所有不完整染色的麻风杆菌都是死菌,(2) 在鼠足垫内查菌阴性,则表明在动物体中无麻风杆菌生长。前一种论点可以导致临床研究者断言,在以有效的抗麻风药物B663治疗麻风一年后而被误认为出现抗药性,几乎将其舍弃而不再用。后一种论点则导致研究者采用低剂量药物治疗,因而引起世界的性DDS抗药性。本文概述这个论据,即并不是所有的不完整麻风杆菌都是死菌,因为用现在的“标准足垫/麻风杆菌技术”并不能查出足垫中存在的所有麻风杆菌。
Since the discovery of a mouse footpad that has allowed the growth of M. leprae, there has been an over-emphasis on laboratory results in clinical practice, which has led to some tragic consequences in the area of leprosy. There are two well-known examples worth citing. It is based on the following two arguments: (1) All lemmas that are incompletely stained are dead, (2) bacteria negative in the mouse footpad indicates that in animals No leprosy growth. The former argument could lead clinical investigators to assert that one year after treatment with leprosy B663, an effective anti-leprosy drug, was mistaken for resistance and almost discarded and no longer used. The latter argument led to researchers using low-dose medications, which led to the world’s sexual DDS resistance. This article outlines the argument that not all incomplete leprosy bacteria are dead, as the current “standard footpads / leprosy technology” does not detect all leprosy present in footpads.