Boosting of the enhanced permeability and retention effect with nanocapsules improves the therapeuti

• 作 者: Chao Yang Yanli Tan Hongzhao Q
• 机 构: DepartmentofNeurosurgery,TianjinNeurologicalInstitute,DepartmentofPathology,DepartmentofPathology,Ti
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2020年2期
• 关键词: Endothelial cells EPR effect NANOCAPSULE single dose administration therapeutic
• 基金项目: the National Key Research and Development Program(Grant Nos.2016YFC0902502 and 2018YFA0209700),the National Natural Science Foundation of China(Grant Nos.81772667 and 51773151),the Special Constructio

Objective:The introduction of therapeutic antibodies(tAbs)into clinical practice has revolutionized tumor treatment strategies,but their tumor therapy efficiency is still far below expectations because of the rapid degradation and limited tumor accumulati