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目的探讨拉莫三嗪添加-替换丙戊酸治疗癫痫疗效研究。方法 2014年1月—2015年9月选取50例经丙戊酸治疗无效的癫痫患者作为研究对象,治疗期间增加使用拉莫三嗪进行治疗,并逐渐替代丙戊酸,观察患者各阶段的用药效果、拉莫三嗪的血药浓度及不良反应发生情况,数据进行统计学处理,P<0.05为差异有统计学意义。结果完成拉莫三嗪联合丙戊酸治疗41例,占比82.00%,完成拉莫三嗪单药治疗31例,占比62.00%;药物联合治疗总好转概率为80.49%,单独用药治疗总好转概率为77.42%,药物联合治疗阶段拉莫三嗪的血药浓度明显较单独用药治疗阶段高(P<0.05)。结论在拉莫三嗪的用药剂量不变的情况下,联合使用丙戊酸,患者的血药浓度明显较单独用药患者的高。
Objective To investigate the efficacy of lamotrigine in addition to valproic acid in the treatment of epilepsy. Methods From January 2014 to September 2015, 50 patients with epilepsy treated with valproic acid were selected as the research object. The patients were treated with lamotrigine and gradually replaced with valproic acid during the treatment period, and the patients in all stages were observed. Effect, lamotrigine blood concentration and adverse reactions, data for statistical analysis, P <0.05 for the difference was statistically significant. Results The complete lamotrigine and valproic acid treatment in 41 cases, accounting for 82.00%, complete lamotrigine monotherapy in 31 cases, accounting for 62.00%; drug combination therapy, the overall improvement probability was 80.49%, the overall improvement of drug treatment alone The probability was 77.42%. The plasma concentration of lamotrigine in the combined treatment phase was significantly higher than that in the single treatment phase (P <0.05). Conclusions In the same dose of lamotrigine, the combination of valproic acid, the patient’s plasma concentration was significantly higher than the drug alone.