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一、体内外抗菌活性 E-1040的抗菌谱广,它对革兰氏阳性、阴性菌,包括绿脓杆菌均有效。它是目前抗绿脓杆菌活性最强的化合物。它能快速杀死临床分离得到的枸橼酸杆菌。与头孢他定(CAZ)相比较,CAZ经6小时作用后,细菌重新复活,并产生对CAZ高度耐药的变种菌,而E-1040组经12小时作用后,细菌复活及耐药变种菌现象均未出现。对阴沟肠杆菌、绿脓杆菌的杀菌作用也相同。可以认为这是E-1040对酶的低亲和力所致。然而它对拟杆菌无抑制作用。E-1040对各种β-内酰胺酶均稳定。细菌形态学的研究表明,还能导
First, the antibacterial activity in vitro E-1040 antibacterial spectrum wide, it is Gram-positive, negative bacteria, including Pseudomonas aeruginosa are effective. It is currently the most potent anti-Pseudomonas aeruginosa compound. It quickly kills clinically isolated Citrobacter. Compared with ceftazidime (CAZ), after 6 hours of CAZ, the bacteria resumed and produced highly resistant variant strains of CAZ. After 12 hours of treatment, the bacteria resuscitated and resistant mutant strains Phenomenon did not appear. Enterobacter cloacae, Pseudomonas aeruginosa bactericidal effect is the same. It can be considered that this is due to the low affinity of E-1040 for the enzyme. However, it does not inhibit Bacteroides. E-1040 is stable against various β-lactamases. Bacterial morphological studies have shown that it can guide