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目的:探讨血浆血小板α颗粒膜蛋白(GμP－140)水平的变化在原发性肾病综合征(PNS)中的意义.方法:用放免法测定了24例PNS病人和20例正常的血浆GMP－140水平,同时测定末梢血小板(PLT)计数、血浆凝血酶原时间(PT)、血浆纤维蛋白原(FIB)定量、血及尿中纤维蛋白(原)降解产物(FDP).结果:PNS病人血浆GMP－140水平高于正常对照组(P＜0.05),同时PLT、血浆FIB、尿FDP水平明显升高(P＜0.01).PNS病人血浆GMP－140水平与24H尿蛋白定量呈正相关(γ＝0.56,P＜0.01).结果:血浆GMP－140水平是反映血小板活化的良好指标,血小板活化与肾小球滤过屏障损伤有关.“,”Objective:To discuss the significance of plasma GMP 140 in patients with primary Nephrotic Syndrome(PNS).Methods:The plasma level of GMP 140 was measured among PNS group ( n =24) and control group( n =20) using radioimmunity method.Platelet(PLT), plasma prothrombin time (PT),fibrinagen (Fib) and fibringen derived praduets (FDP) in blood and urine were measured too. Results:The plasma level of GMP 140 was much higher in the PNS group than that in the c...