论文部分内容阅读
用磷酸三酯法在溶液中合成了两个带有3’－（S）-胸腺嘧啶基-4’－（R）一羟基-5’－（S）-羟甲基四氢呋喃的三脱氧核苷酸3和4．与三脱氧核苷酸（2）相比，化合物3和4对核酸酶SI具有更大的稳定性．
Two tridecoxynucleosides with 3 ’- (S) -thyminyl-4’ - (R) monohydroxy-5 ’- (S) -hydroxymethyltetrahydrofuran were synthesized in solution using the phosphotriester method Acids 3 and 4. Compounds 3 and 4 have greater stability to nuclease SI than trideoxynucleotide (2).