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目的探讨垂体瘤转化基因(PTTG),碱性成纤维细胞生长因子(bFGF)及血管内皮生长因子(VFGF)在子宫内膜异位症中表达及意义。方法应用免疫组织化学技术,检测48例子宫内膜异位症及30例正常子宫内膜组织中PTTG、bFGF及VEGF的表达水平。结果在子宫内膜异位症中,PT-TG、bFGF及VEGF的阳性表达率分别是81.2%、77.1%及66.7%,其阳性率及表达等级均明显高于正常子宫内膜组织(P<0.01)。三者均呈正相关关系。结论子宫内膜异位症中PTTG的表达明显高于正常子宫内膜组织,而高表达的PTTG可刺激bFGF和VEGF的表达,三者共同促使子宫内膜异位症的发展。
Objective To investigate the expression and significance of pituitary tumor transforming gene (PTTG), basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VFGF) in endometriosis. Methods Immunohistochemical technique was used to detect the expression of PTTG, bFGF and VEGF in 48 cases of endometriosis and 30 cases of normal endometrium. Results The positive rates of PT-TG, bFGF and VEGF in endometriosis were 81.2%, 77.1% and 66.7%, respectively, which were significantly higher than those in normal endometrium (P < 0.01). All three showed a positive correlation. Conclusions The expression of PTTG in endometriosis is significantly higher than that in normal endometrial tissues. However, the high expression of PTTG can stimulate the expression of bFGF and VEGF, which together promote the development of endometriosis.