论文部分内容阅读
目的:探讨EphB 4与VEGF在直肠癌组织中的表达及临床意义。方法:用免疫组化法检测73例直肠癌术后蜡块标本中EphB 4、VEGF蛋白的表达。结果:直肠癌中EphB 4和VEGF阳性表达率分别为49.32%和54.79%;二者共阳性表达率41.09%(30/70),共阴性表达率36.99%(27/73),具有显著的相关性(P<0.01);二者的表达水平均与直肠癌浸润深度、淋巴结转移有关(P<0.05),与性别、年龄、病理分级无关(P>0.05)。结论:EphB 4与VEGF在直肠癌的表达具有高度一致性,二者的表达水平与直肠癌的侵润深度、淋巴结转移有关。提示EphB 4与VEGF在肿瘤的血管生成及进展过程中发挥协同作用。
Objective: To investigate the expression and clinical significance of EphB 4 and VEGF in rectal cancer. Methods: The expression of EphB 4 and VEGF protein in 73 specimens of rectal cancer after operation were examined by immunohistochemistry. Results: The positive rates of EphB 4 and VEGF in rectal cancer were 49.32% and 54.79%, respectively. The co-positive expression rates were 41.09% (30/70) and 36.99% (27/73) (P <0.01). The expression levels of both were related to the depth of invasion and lymph node metastasis (P <0.05), but not to the gender, age and pathological grade (P> 0.05). CONCLUSION: The expression of EphB 4 and VEGF in rectal cancer is highly consistent. The expression of EphB 4 and VEGF is closely related to the depth of invasion and lymph node metastasis in rectal cancer. These results suggest that EphB 4 and VEGF play a synergistic role in tumor angiogenesis and progression.