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目的了解母体血清抗-HBs水平是否对婴儿乙肝疫苗0-1-6个月接种方案免疫效果产生影响。方法选择2014年1月-2015年12月来滨州市人民医院儿科住院治疗且在该院足月出生,并全程按时完成乙肝疫苗0-1-6个月三针免疫接种程序的8～24月的婴幼儿109名,对婴幼儿血清抗-HBs的定量检测结果与其母住院分娩时血清抗-HBs的定量检测结果进行统计分析。结果母体血清抗-HBs<10 mIU/ml且HBs Ag阴性56例,其婴幼儿乙肝疫苗接种后无应答者6例(10.71%),有应答者50例(89.29%),血清抗-HBs水平为411.39(58.81,1 435.81)mIU/ml;母体血清抗-HBs≥10mIU/ml 53例,其婴幼儿乙肝疫苗接种后无应答者1例(1.89%),有应答者52例(98.11%),其血清抗-HBs水平为457.11(114.54,1 475.49)mIU/ml,母体抗-HBs水平对两组婴幼儿乙肝疫苗免疫应答率差异无统计学意义(χ~2=3.618,P=0.308),两组婴幼儿乙肝疫苗接种后血清抗-HBs水平差异无统计学意义(Z=-0.485,P=0.628);不论母体血清抗-HBs<10 mIU/ml还是≥10 mIU/ml,16～24月龄婴幼儿血清抗-HBs水平均较8～16月龄下降,两者比较差异均有统计学意义(Z=-4.437、-3.742,均P=0.000),而同一月龄段(不论是8～16月龄段间还是16～24月龄间)婴幼儿血清抗-HBs水平差异均无统计学意义(Z=-0.496、-0.881,P=0.620、0.378);对于母体血清抗-HBs≥10 mIU/ml者,其婴幼儿血清抗-HBs水平与母体抗-HBs水平无相关性(r=-0.046,P=0.746)。结论母体血清抗-HBs水平对婴儿乙肝疫苗0-1-6个月接种方案免疫效果不产生影响。
Objective To investigate whether the level of anti-HBs in maternal serum affects the immunization efficacy of vaccination programs of 0-1-6 months in infants with hepatitis B vaccine. Methods From January 2014 to December 2015, Binzhou People’s Hospital was hospitalized in pediatrics and was born in the hospital at full-term. The procedure of three-needle immunization of hepatitis B vaccine for 0-1-6 months was completed on schedule from August to April Of 109 infants and young children, the results of quantitative detection of serum anti-HBs in infants and toddlers were compared with the results of quantitative detection of serum anti-HBs when their infants were hospitalized. Results The serum levels of anti-HBs <10 mIU / ml and HBsAg-negative in maternal serum were 56 (10.71%), 50 (89.29%) with no responders, Were 411.39 (58.81,1 435.81) mIU / ml; maternal serum anti-HBs≥10mIU / ml in 53 cases. There were 1 case (1.89%) of infants with non-responders after vaccination and 52 cases (98.11% , The serum level of anti-HBs was 457.11 (114.54,1 475.49) mIU / ml. There was no significant difference in the level of anti-HBs among the two groups (χ ~ 2 = 3.618, P = 0.308) There was no significant difference in serum anti-HBs level between two groups of infants with hepatitis B vaccination (Z = -0.485, P = 0.628); no significant difference was found in serum anti-HBs level <10 mIU / ml or ≥10 mIU / The levels of serum anti-HBs in 24-month-old infants and young children were all lower than those of 8-16 months old (both Z = -4.437 and -3.742, both P = 0.000) There was no significant difference in serum anti-HBs levels between 8-16 months old and 16-24 months old (Z = -0.496, -0.881, P = 0.620,0.378) HBs ≥ 10 mIU / ml, their infant anti-HBs levels and Anti-body levels -HBs no correlation (r = -0.046, P = 0.746). Conclusion The level of anti-HBs in maternal serum does not affect the immunization efficacy of vaccination programs of 0-1-6 months in infants with hepatitis B vaccine.