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的：了解间质内放射治疗脑深部肿瘤的效果，以利于提高间质内放射疗效。方法：在不同时间段，应用３ 种不同方式和剂量对 １７３ 例患者脑深部肿瘤进行间质内放射治疗，分期进行追踪随访。结果：全组无手术死亡，随访 ５～８２ 个月，其中星形细胞瘤Ⅰ～Ⅱ级 ３ 年生存率为 ５４．５％ ，５ 年生存率为３８６％ ；Ⅲ～Ⅳ级 １ 年生存率为１１．６％ ，２ 年生存率为７２０％ ，３ 年生存率为１６２％ 。影像学随访结果：肿瘤完全消失１５ 例（８．７％ ）；肿瘤直径缩小在８０％ 以上的２９ 例（１６．８％ ）；缩小３０％ ～５０％者８１ 例（４６．８％ ）。完全消失的肿瘤为颅内恶性淋巴瘤、松果体区生殖细胞瘤、部分成胶质细胞瘤和转移瘤等。结论：为减少照射后的并发症，提高治疗效果，对颅内不同部位和不同性质肿瘤的内放射治疗应选用不同的照射剂量，以超分割内照射加外照射方法较优。
: To understand the effect of interstitial radiation treatment of deep brain tumors, in order to facilitate the improvement of interstitial radiation effects. Methods: At different time periods, 173 patients with deep brain tumors were treated with interstitial radiation by 3 different ways and doses, and were followed up by stages. Results: There was no operative death in the whole group. The follow-up ranged from 5 to 82 months. The three-year survival rate was 54.5% in grade Ⅰ ~ Ⅱ astrocytoma and 386% in three-year grade Ⅲ-Ⅳ The survival rate was 11.6%, the 2-year survival rate was 720%, and the 3-year survival rate was 162%. Imaging follow-up results: 15 cases (8.7%) disappeared completely; 29 cases (16.8%) reduced tumor diameter more than 80%; 81 cases (46.8%) narrowed 30% -50%. Completely disappeared tumor for intracranial malignant lymphoma, pineal region germ cell tumor, some glioblastoma and metastases. Conclusion: In order to reduce post-irradiation complications and improve the therapeutic effect, different radiation doses should be used for intracranial radiotherapy of different parts and different types of tumors, and the method of hyperfractionated internal irradiation plus external irradiation is preferable.