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以低硒酵母配制的低硒基础饲料（含硒量为０．０１ｍｇ／ｋｇ）和在此基础上加亚硒酸钠配成硒水平为０．５０ｍｇ／ｋｇ的足硒饲料来喂养雄性Ｗｉｓｔａｒ断乳大鼠。于０、１、２、４、６、８、１２、１５、１７、１９、２０和２４周时处死大鼠取其组织，分别对各种组织中的硒、细胞内谷胱甘肽过氧化物酶（ｃＧＰＸ）、细胞外谷胱甘肽过氧化物酶（ｅＧＰＸ）、磷脂氢谷胱甘肽过氧化物酶（ＰＨＧＰＸ）、Ⅰ型脱碘酶（ＩＤⅠ）和Ⅱ型脱碘酶（ＩＤⅡ）活性进行动态观察。结果发现睾丸中的硒和脑垂体中的ｃＧＰＸ在耗竭过程中降低速度较其它组织慢，且降低幅度较小；而硒蛋白中ＩＤⅠ和ＰＨＧＰＸ对硒的利用优先于ｃＧＰＸ和ｅＧＰＸ，ＰＨＧＰＸ和ＩＤⅠ的功能可能比ｃＧＰＸ和ｅＧＰＸ更重要。
Low-selenium-based basal diet containing selenium (0.01 mg / kg selenium) and basal selenium supplemented with selenium at 0.50 mg / kg were used to feed male Wistar rats Dairy rats. The rats were sacrificed at 0, 1, 2, 4, 6, 8, 12, 15, 17, 19, 20 and 24 weeks for tissue selenium, (CGPX), extracellular glutathione peroxidase (eGPX), phospholipid hydroperoxide glutathione peroxidase (PHGPX), type I deiodinase (IDⅠ) and type Ⅱ deiodinase (IDⅡ ) Activity was observed dynamically. The results showed that the selenium and pituitary gland in the testis decreased slowly in the process of depletion compared with other tissues, and the extent of decrease was lower. However, selenoprotein IDⅠand PHGPX had higher selenium utilization than those of cGPX and eGPX, PHGPX and IDⅠ Functionality may be more important than cGPX and eGPX.