论文部分内容阅读
近年来发现高血压患者和实验动物钙离子代谢有各种异常,血中钙离子水平和血浆肾素活性(PRA)关系密切。低肾素型高血压患者的血清钙离子水平较低,据推测其细胞内水平较高;如改变钙在细胞内外间隙的分布,可望更有效地降低此型患者的血压。为此,作者研究了口服单剂硝苯啶对血清钙离子、PRA、醛固酮(PA)和血压的影响。方法:25例患者均符合原发性高血压的诊断标准,包括三次不同时间测量的血压均>150/95mmHg,血清钾离子正常,并除外继发性高血压。试验前,患者或未接受降压治疗,或停用降压药至少
In recent years, found in hypertensive patients and experimental animals have various abnormal calcium metabolism, blood levels of calcium and plasma renin activity (PRA) are closely related. Patients with low renin hypertension have lower serum calcium levels, presumably higher intracellular levels; such as changing the distribution of calcium in the gap between cells and outside the body, is expected to be more effective in reducing blood pressure in this type of patients. To this end, the authors investigated the effects of oral single doses of nifedipine on serum calcium, PRA, aldosterone (PA), and blood pressure. Methods: All 25 patients met the diagnostic criteria of essential hypertension, including blood pressure> 150 / 95mmHg measured at three different times, normal serum potassium level, with the exception of secondary hypertension. Before the test, patients either did not receive antihypertensive treatment or at least discontinue antihypertensive drugs