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作者考察了三氟甲基(口恶)唑酮与缺电子烯烃在不同条件下的反应,发现了三氟甲基(口恶)唑酮与α-氯代丙烯腈的串联Micheal加成一类Mannich反应-脱羧消除反应.提供了分别通过1,3-偶极环加成反应和串联的环合反应从三氟甲基(口恶)唑酮直接合成三氟甲基吡咯及其有关三氟甲基杂环化合物的方法.
The authors investigated the reaction of trifluoromethyl (oxazolidinone) with an electron deficient alkene under different conditions and found a series of Mannich additions of tandem Micheal addition of trifluoromethyl (oxazolidinone) and a-chloroacrylonitrile The reaction-decarboxylation elimination reaction provides for the direct synthesis of trifluoromethylpyrrole and its related triflates from trifluoromethyl (oxazolidinone) by a 1,3-dipolar cycloaddition reaction and a tandem cyclization reaction, respectively Based heterocyclic compounds.