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目的：探讨氯沙坦钾对高血压患者血管内皮功能的保护作用。方法选取200例原发性高血压患者作为治疗组，同期体检正常的200例健康者作为对照组，治疗组给予氯沙坦钾50mg，1次/d，2w后，如果收缩压≥140mmHg或舒张压≥90mmHg，则增加至100mg，1次/d。再经1w后未达标，给予氢氯噻嗪片12.5mg，1次/d，共8w。治疗前和治疗8w后测定内皮素-1(ET-1)水平、血浆一氧化氮(NO)水平、24h尿微量白蛋白(24hU-MALB)。对照组仅测定1次。测量血压2次/d。观察治疗前、后血压、ET-1、NO和24hU-MALB变化，同时观察有无相关不良反应。结果治疗组治疗8周后血压、ET-1、NO和24hU-MALB均较治疗前明显改善(<0.01)，未发现明显不良反应。结论氯沙坦钾降压作用安全、有效，能纠正ET-1和NO平衡紊乱，减少24h尿微量白蛋白，延缓肾脏疾病的进展，改善高血压病患者的内皮功能。“,”Objective To explore potassium chloride sand jotham the protective ef ects of endothelial function in patients with hypertension.Methods Select 200 cases of primary hypertension patients as treatment group,the same physical examination of 200 cases of normal healthy subjects as control group.The treatment group given losartan potassium 50 mg,1 times a day.Two weeks later,if the systolic pressure is greater than or equal to 140 mmHg or diastolic blood pressure is greater than or equal to 90 mmHg,increased to 100 mg,1 times a day.After 1 week again not up to standa,give Hydrochlorothiazide Tablets 12.5mg,1 times a day,a total of eight weeks.Before and after 8 weeks treatment determination of endothelin-1 (ET-1)、Plasma-nitric oxide (NO)、24-hour urine Trace albumin (24hU-MALB).Deter-mination of the control group only 1 times.Measuring blood pressure 2 times a day.Observed before and after treatment of blood pressure、ET-1、NO and 24hU-MALB changes.At the same time observe any adverse reaction.Results Treatment group 8 weeks after treatment, blood pressure、ET - 1、NO and24hU-MALB are obviously improved ( <0.01).Found no obvious adverse reactions.Conclusion Losartan Potassium Lower blood pressure ef ect safe and ef ective,to correct the balance disorders ET- 1 and NO,reduce the 24-hour urine trace albumin,delay the progress of kidney disease,improvement of endothelial function of hypertension patients.