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目的探讨复方降脂胶囊对高脂血症大鼠模型早期发病的治疗作用,为更好的开发和应用此药提供实验依据。方法采用高脂饲料喂养40只Wistar大鼠,建立大鼠高脂血症模型,将复方降脂胶囊分为大、中、小3个剂量,以血清中TC、TG、HDL-C、LDL-C以及ox-LDL和SOD的含量为观测指标,观察药物的降脂疗效。结果中、大剂量治疗组TC、TG、LDLC水平显著低于高脂血症模型组(P<0.05),HDL-C的水平显著性增高(P<0.05);药物治疗组与高脂血症模型组比较,血清中ox-LDL含量降低非常显著(P<0.01),SOD含量显著升高(P<0.05)。结论复方降脂胶囊能够降低高脂血症模型大鼠血液中TC、TG、LDL-C和ox-LDL的水平,升高HDL-C、SOD的水平。
Objective To investigate the therapeutic effect of Fufang Jiangzhi Capsule on the early onset of hyperlipidemic rat model and to provide experimental evidence for better development and application of this drug. Methods Forty Wistar rats were fed with high-fat diet. The model of hyperlipidemia in rats was established. The compound lipid-lowering capsules were divided into three groups: large, medium and small. The levels of TC, TG, HDL- C and ox-LDL and SOD content as the observation index, observe the drug lipid-lowering efficacy. The results showed that the level of TC, TG and LDLC in the high-dose treatment group was significantly lower than that in the hyperlipidemia model group (P <0.05), and the level of HDL-C was significantly increased (P <0.05) Compared with model group, the content of ox-LDL in serum decreased significantly (P <0.01) and the content of SOD increased significantly (P <0.05). Conclusion Fufang Jiangzhi Capsule can reduce the levels of TC, TG, LDL-C and ox-LDL in blood and increase the levels of HDL-C and SOD in hyperlipemia model rats.