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目的：探讨子痫前期孕妇血清炎性标志物水平测定的临床意义。方法免疫比浊法等检测87例子痫前期孕妇血清内皮素（endothelium, ET）、D-二聚体（D-dimer, D-D）、C-反应蛋白（C-reactive protein, CRP）和脂蛋白相关磷脂酶A2（lipoprotein-associated phospholipase A2, Lp-PLA2）水平并与62例正常孕妇进行比对性分析。采用受试者工作特征曲线（ROC曲线）分析ET、D-D、CRP和LP-PLA2水平评估子痫前期孕妇早期诊断的临床价值。结果子痫前期孕妇血清ET、D-D、CRP和LP-PLA2水平较正常孕妇明显增高（P＜0.001或P＜0.01），血清ET与血清D-D、CRP和LP-PLA2呈正相关（r=0.7542、0.5618、0.8643，P均＜0.01）。ROC曲线分析表明：血清ET、D-D、CRP和LP-PLA2水平评估子痫前期孕妇早期诊断的AUC分别为0.915、0.691、0.753和0.892；截断值分别为80.18 ng/mL、421.32μg/L、0.71 mg/L和152.78 ng/mL；敏感度分别为85.6%、62.8%、67.3%和84.3%；特异度分别为94.3%、60.6%、65.2%和92.8%。以血清ET和LP-PLA2水平为最佳。结论炎性标志物是早期诊断子痫前期孕妇有价值指标，并以血清ET和LP-PLA2水平为好。“,”Objective To explore clinical signifi cance of determining serum infl ammatory markers in patients with pre-eclampsia women.Methods Serum endothelium (ET), D-dimer (D-D), C-reactive protein (CRP), and lipoprotein-associated phospholipase A2 (LP-PLA2) levels were determined in 87 patients with per-eclampsia and 62 cases normal women by immunoturbidimetry etc. and compared analysis was done. The receiver operating characteristic (ROC) curve was plotted to analyze ET, D-D, CRP and Lp-PLA2 as a prognostic clinical value indicators of pre-eclampsia women early diagnosis.Results The serum ET, D-D, CRP and Lp-PLA2 levels of patients with pre-eclampsia were signifi cantly higher than those of normal women (P<0.001 orP<0.01). Serum ET level was positively correlated with serum D-D, CRP and LP-PLA2 levels (r=0.7542, 0.5648, and 0.8643,P all<0.01). ROC curve analysis showed that AUC for per-eclampsia women early diagnosis were 0.915, 0.691, 0.753 and 0.892 respectively; Cut-off value were 80.18 ng/mL, 421.32μg/L, 0.71 mg/L and 152.78 ng/mL respectively; Sensitivity were 85.6%, 62.8%, 67.3% and 84.3% respectively; Specifi city were 94.3%, 60.6%, 65.2% and 92.8% respectively. The serum ET and Lp-PLA2 were best.Conclusion The infl ammatory markers are valuable indexes for early diagnosis in patients with pre-eclampsia women. The serum ET and Lp-PLA2 are best.