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Ｅ－钙粘附素失活及其基因突变对恶性肿瘤侵袭倾向的影响许洪卫，王元和，高瀚肿瘤浸润、转移等恶性表型是瘤细胞与细胞外基质相互作用的结果，其关键步骤是瘤细胞脱离原发灶并再附着转移部位［１］。钙粘附素（ｃａｄｌｅｒｉｎ，Ｃｄ）超家族细胞粘附受体主要介导正常和...
Effects of inactivation of E-cadherin and its mutations on the aggressiveness of malignant tumors Xu Hongwei, Wang Yuanhe, Gao Yao The malignant phenotypes of tumor invasion and metastasis are the results of the interaction between tumor cells and extracellular matrix. The tumor cells are detached from the primary tumor and reattached to the site of metastasis [1]. The cadherin (Cd) superfamily of cell adhesion receptors mediates normal and ...