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目的:研究凋亡抑制基因survivin在乳腺癌中表达的预后价值。方法:采用免疫组化SP法检测180例乳腺癌石蜡标本中survivin表达情况,并对survivin表达与乳腺癌的临床分期、雌激素受体表达、月经状况、腋淋巴结转移、病理类型、无病生存时间以及总生存时间的关系进行了分析。结果:Survivin在乳腺癌中的阳性表达率为66.1%,survivin的表达与乳腺癌的临床分期、雌激素受体、月经状况、腋淋巴结是否转移及病理类型无关(P>0.05);单因素分析结果表明survivin表达与乳腺癌病人的无病生存时间和总生存时间显著相关,survivin表达阳性病人的无病生存时间和总生存时间均显著低于survivin表达阴性的病人;多因素Cox回归分析结果表明survivin的表达状况是决定乳腺癌病人无病生存时间的独立因素,而与总生存时间无关。结论:Survivin是判断乳腺癌预后的一个独立生物学指标,阳性表达病人的预后较阴性表达病人差。
AIM: To investigate the prognostic value of survivin, an inhibitor of apoptosis, in breast cancer. Methods: Survivin expression in paraffin-embedded specimens from 180 cases of breast cancer was detected by immunohistochemical SP method. Survivin expression was correlated with clinical stage, estrogen receptor expression, menstrual status, axillary lymph node metastasis, pathological type, disease-free survival Time and total survival time of the relationship was analyzed. Results: The positive expression rate of Survivin in breast cancer was 66.1%. The expression of survivin was not correlated with clinical stage, estrogen receptor, menstrual status, axillary lymph node metastasis and pathological type (P> 0.05) The results showed that survivin expression and breast cancer patients with disease-free survival time and overall survival time was significantly correlated with survivin expression-positive patients disease-free survival time and overall survival time were significantly lower than survivin expression was negative patients; multivariate Cox regression analysis showed The expression status of survivin is an independent factor that determines the disease-free survival time of breast cancer patients, but not with the overall survival time. Conclusion: Survivin is an independent biological index to judge the prognosis of breast cancer. The prognosis of patients with positive expression is worse than that of patients with negative expression.