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以伯氏疟原虫小鼠体内试验系统,采用药物剂量递增法培育本芴醇、8101和A+B复方3个抗药虫株。经连续血传140代,历时980天,其抗性指数(I_(90))分别为410、212.4和48.5。本芴醇在培育的第5代,8101及A+B复方在第10代开始出现抗药性;I_(90)峰值及达到峰值的代数为410/30p、235.6/120p及48.5/140p。在每次转种前72h分别单次灌胃本芴醇500mg/kg、8101 300mg(基质)/kg和A+B复方80mg/kg可维持各自的抗性水平。3个抗药虫株对所测试的10种药物均出现了程度不等的交叉抗药性。
In vivo test of Plasmodium berghei mice, three drug-resistant strains of benflumetol, 8101 and A + B were cultivated with increasing drug dose. After 140 generations of continuous blood transmission, which lasted 980 days, the resistance index (I_ (90)) was 410, 212.4 and 48.5 respectively. Benflumetol at the 5th, 8101 and A + B phases developed resistance at the 10th generation. The peak values of I_ (90) and their peaks were 410/30, 235.6 / 120 and 48.5 / 140p, respectively. The respective levels of resistance to each of lumeflulin 500 mg / kg, 8101 300 mg (matrix) / kg, and A + B compound 80 mg / kg were administered intragastrically at 72 h prior to each transfection. The three resistant strains showed varying degrees of cross-resistance to the ten drugs tested.