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目的观察奥美拉唑三联方案治疗幽门螺杆菌阳性十二指肠球部溃疡的有效性和安全性。方法将2006年1月～2007年12月中90例患者应用奥美拉唑、羟氨苄青霉素、甲硝唑三联治疗Du的有效性和安全性进行临床对比观察,以雷尼替丁、羟氨苄青霉素、甲硝唑、枸橼酸铋钾胶囊四联疗法作为对照组。结果奥美拉唑和雷尼替丁2周、4周、8周的溃疡愈合率分别为68%、99%、100%与48%、88%、97%。结论奥美拉唑三联方案治疗幽门螺杆菌阳性十二指肠球部溃疡有效、安全,且价格适宜。
Objective To observe the efficacy and safety of omeprazole triple regimen in the treatment of Helicobacter pylori-positive duodenal ulcer. Methods The clinical efficacy and safety of omeprazole, amoxicillin and metronidazole in the treatment of Du from January 2006 to December 2007 in 90 patients were compared with each other. The effects of ranitidine, Penicillin, metronidazole, bismuth potassium citrate capsule quadruple therapy as a control group. Results The ulcer healing rates of omeprazole and ranitidine were 68%, 99%, 100% and 48%, 88% and 97% at 2, 4 and 8 weeks respectively. Conclusion Omeprazole triple therapy for Helicobacter pylori positive duodenal ulcer is effective, safe and affordable.