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目的:探讨乙型肝炎病毒基因型与临床表现及干扰素联合猪苓多糖抗病毒治疗后HBV DNA、HB eA g的关系。方法:研究病例39例,入选病例32例,采用微板核酸杂交-EL ISA法进行基因分型,干扰素a-2b 500万u,每周3次,疗程6个月;同时给予猪苓多糖4 mL,1次/d,疗程2个月,观察HBV DNA、HB eA g、HB eA g/抗-HB e的变化。结果:32例样本中,B型,C型,B、C混合型分别为37.5%、50%、12.5%,发现家族中连续二代基因型的变化,同时发现联合抗病毒治疗的疗效并未在基因亚型中产生差异。结论:慢性HBV感染者不同类型肝病中基因型B和基因型C所占比例有差异。从家族中连续二代基因型的变化可以看出,基因分型又是相对的,基因亚型间存在自然的变异。
Objective: To investigate the relationship between hepatitis B virus genotypes and clinical manifestations, HBV DNA and HBeA g after interferon plus polypolluate antiviral therapy. Methods: Thirty-nine cases were studied and 32 cases were enrolled. Genotyping was performed using microplate nucleic acid hybridization-ELISA. Interferon a-2b 5 million u was given three times a week for 6 months. Polyporus polysaccharide 4 mL once a day for 2 months. The changes of HBV DNA, HB eA g and HB eA g / anti-HBe were observed. Results: In the 32 samples, the genotypes B, C, B and C were 37.5%, 50% and 12.5%, respectively. The genotypes of the second generation in the family were found to be different, and the efficacy of combined antiviral therapy was not found Differences in genotypes. Conclusion: There are differences in the proportion of genotype B and genotype C between different types of liver diseases in chronic HBV infection. As can be seen from the second generation of genotypes in the family, genotyping is relative and there are natural variations among the subtypes.