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目的:探讨RegⅣ基因在食管癌变过程中的表达。方法:应用免疫组织化学S-P法检测RegⅣ基因在17例癌变组和40例非癌变组中的表达。结果:RegⅣ在癌变组中的表达增高(P<0.05)。结论:RegⅣ基因的表达和食管癌的发生有关,该基因表达的变化可能是食管癌变过程中的早期事件。
Objective: To investigate the expression of RegⅣ gene in esophageal carcinogenesis. Methods: Immunohistochemical S-P method was used to detect the expression of RegⅣ gene in 17 cancerous and 40 non-cancerous cases. Results: The expression of RegⅣ in carcinogenesis group was increased (P <0.05). Conclusion: The expression of Reg Ⅳ gene is related to the occurrence of esophageal cancer. The change of gene expression may be an early event in esophageal carcinogenesis.