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乙型肝炎是严重危害人类健康的疾病。感染乙肝病毒后的转归与机体的免疫状态密切相关。从免疫学的观点看,治疗乙肝的关键是恢复慢性HBV感染患者体内有效的T细胞反应。已有研究证实机体免疫系统可以通过非细胞破坏性机制清除cccDNA,故乙肝的免疫调节治疗正受到人们的广泛关注。
Hepatitis B is a disease that seriously affects human health. The outcome after infection with hepatitis B virus is closely related to the immune status of the body. From an immunological point of view, the key to treating hepatitis B is to restore an effective T cell response in patients with chronic HBV infection. Studies have confirmed that the body’s immune system can be cleared of cccDNA by a non-cellular destructive mechanism, so immunomodulatory treatment of hepatitis B is receiving widespread attention.