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目的:了解荆州市第一人民医院儿童药品不良反应(ADR)发生的特点及一般规律,为临床安全合理用药提供参考。方法:对荆州市第一人民医院2010年1月至2012年2月临床各科室上报的138例儿童ADR进行统计、分析。结果:138例ADR报告中,1～3岁儿童发生率最高(34.06%),其最常见的临床表现为皮肤及其附件损害(65.54%)。引发ADR的药物以头孢菌素类最多(47.06%)。结论:应重视儿童ADR的监测,提高安全合理用药水平。
Objective: To understand the characteristics and general rules of ADR in Jingzhou First People ’s Hospital and provide reference for clinical safety and rational drug use. METHODS: The ADRs of 138 children reported by clinical departments of Jingzhou First People’s Hospital from January 2010 to February 2012 were analyzed statistically. Results: The highest incidence of children aged 1-3 years (34.06%) was found in 138 cases of ADR. The most common clinical manifestation was the damage of skin and its accessory (65.54%). The drugs that cause ADR are mostly cephalosporins (47.06%). Conclusion: We should pay attention to the monitoring of ADR in children to improve the safe and reasonable medication level.