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应用抗人Ｔ淋巴细胞单克隆抗体ＯＫＴ系列检测３０例健康老年人，４２例慢性肺心病，１５例恶性肿瘤，２１例高血压病患者外周血Ｔ淋巴细胞亚群的变化。结果显示，慢性肺心病组及恶性肿瘤组ＯＫＴ３百分率、ＯＫＴ４百分率显著降低，ＯＫＴ８百分率无明显变化，致ＯＫＴ４／ＯＫＴ８比值降低。慢性肺心病急性加重期ＯＫＴ３百分率和ＯＫＴ４百分率低于缓解期。结果提示老年人细胞免疫功能减弱，尤其是Ｔ淋巴细胞亚群比例失调是导致感染、恶性肿瘤等多种老年病的发生、发展的重要原因之一。
OKT series of anti-human T lymphocyte monoclonal antibody was used to detect the changes of T lymphocyte subsets in peripheral blood of 30 healthy elderly, 42 chronic cor pulmonale, 15 malignant tumors and 21 hypertensive patients. The results showed that OKT3 percentage and OKT4 percentage were significantly decreased in chronic pulmonary heart disease group and malignant tumor group, OKT8 percentage did not change significantly, and OKT4 / OKT8 ratio decreased. The percentage of OKT3 and OKT4 in acute exacerbation of chronic pulmonary heart disease was lower than that of remission. The results suggest that elderly patients with weakened cellular immune function, especially the proportion of T lymphocyte subsets imbalance is one of the important reasons for the occurrence and development of a variety of gerontal diseases such as infections and malignancies.