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目的探讨老年慢性阻塞性肺疾病急性期(AECOPD)血浆P物质(SP)测定的临床意义。方法以39例AECOPD老年患者和32例COPD稳定期老年患者为研究对象,30例老年健康体检者为对照组,采用酶联免疫吸附法(ELISA)检测各组血浆SP浓度,计算BODE指数评分,比较COPD患者血浆SP浓度和BODE指数相关性。观察AECOPD老年患者1年死亡率和急性发作者血浆SP浓度情况。结果 AECOPD老年患者血浆SP浓度显著高于稳定期COPD老年患者及老年健康对照组(P<0.01);而稳定期COPD老年患者血浆SP浓度明显高于老年健康对照组(P<0.01)。AECOPD老年患者血浆SP浓度与BODE指数评分呈正相关(P<0.01)。死亡和1年内2次以上急性发作者血清SP浓度明显升高(P<0.05)。结论 AECOPD老年患者血浆SP水平可以判断COPD病情严重程度和预后,对AECOPD老年患者的治疗有所帮助。
Objective To investigate the clinical significance of plasma substance P (SP) in senile patients with chronic obstructive pulmonary disease (AECOPD). Methods Thirty-nine elderly patients with AECOPD and 32 elderly patients with stable COPD were enrolled in this study. Thirty healthy controls were used as controls. Plasma SP concentrations were measured by enzyme-linked immunosorbent assay (ELISA), BODE index was calculated, The correlation between plasma SP concentration and BODE index was compared between COPD patients. Observe the 1-year mortality and the plasma SP concentration of acute onset in AECOPD elderly patients. Results The plasma SP concentration in elderly patients with AECOPD was significantly higher than that in elderly patients with stable COPD and elderly healthy controls (P <0.01). The plasma SP concentration in elderly patients with stable COPD was significantly higher than that in elderly healthy controls (P <0.01). AECOPD elderly patients with plasma SP concentration and BODE index score was positively correlated (P <0.01). Serum SP concentrations were significantly higher in those who died and were more than 2 times within 1 year (P <0.05). Conclusion The level of plasma SP in elderly patients with AECOPD can determine the severity and prognosis of COPD, which may be helpful for the treatment of elderly patients with AECOPD.