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小儿皮疹与乙型肝炎病毒有关,首先由 Gianotti报导,并命名为小儿丘疹性肢皮炎(Gianotti 病)。本病特点是小儿四肢、臀部、颜面部发生特征性皮疹,浅表淋巴结肿大,肝脏肿大,合并急性非黄疸性肝炎,乙型肝炎抗原阳性。1957年他与 Crosti 又报告多例,以后在各国均有报导,因此,亦有奇-柯综合征之称。但是最近认为,奇-柯综合征与 Gianotti 病并不完全一致。在后者,特征性的皮肤改变、急性非黄疸性肝炎是必发的。而 Gianotti 病又与所谓的 Gianotti综合征不同,因后者侵及小儿的四肢,皮疹性状和分布亦不一样,常无肝炎并发。故认为奇-柯综合征是将上述两种疾病混为一谈的结果,这一病名似欠妥当。
Pediatric rash is associated with hepatitis B virus and was first reported by Gianotti and named as pediatric pimple dermatitis (Gianotti disease). The disease is characterized by pediatric limbs, buttocks, facial features rash, superficial lymph nodes, enlarged liver, acute non-icteric hepatitis, hepatitis B antigen positive. In 1957 he and Crosti also reported a number of cases, later reported in all countries, therefore, there are also odd - Ke Syndrome, said. But recently that the odd-Cauchy syndrome and Gianotti disease is not exactly the same. In the latter, the characteristic skin changes, acute non-icteric hepatitis is essential. The Gianotti disease and the so-called Gianotti syndrome is different, because the latter affects children’s limbs, rash traits and distribution are not the same, often without complications of hepatitis. Therefore, Kei-Ke syndrome is the result of confounding the above two diseases, the disease name seems to be inappropriate.