An interview with Mingjie Zhang:phase separation in biological systems

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Mingjie Zhang is a distinguished structural biologist whose research interest is the protein assemblies in cells,particularly those at the synapse,where two neurons meet and transmit nervous impulses from one to the other.In recent years,his group discovered the phenomenon of phase separation in both the pre-and post-synaptic sites of neurons and elucidated its regulation and physiological function.In this interview,NSR Executive Editor-in-Chief Mu-ming Poo talks with Prof.Zhang on the fast-developing research area of biological phase separation,as well as Zhang\'s new role as the Founding Dean of the School of Life Sciences at Southern University of Science and Technology(SUSTech) in Shenzhen.rnBIOLOGICAL PHASE SEPARATION ConceptrnPoo:Phase separation has become one of the hottest topics in cell biology.Why?rnZhang:Phase separation is a well-established phenomenon in physical sciences,and has been observed for a long time in bi-ology.More than 100 years ago,Ramón Cajal discovered con-densed bodies in the nucleus,which are now known as Cajal bodies and their formation is a phase separation process.
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