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目的探讨呼吸道疾病患儿外周血淋巴细胞(PBL)CD2 3百分率的变化及临床意义。方法利用间接玫瑰花结法测定了 2 0例支气管肺炎患儿 (A组 )及 9例毛细支气管炎并心衰的重症肺炎患儿 (B组 )PBL的CD2 3 百分率 ,并用ELISA方法测定了B组血清总IgE水平。结果与正常对照组比较 ,A组CD2 3 百分率增高 ,且急性期患儿高于恢复期患儿。B组血清总IgE水平亦明显增高。结论PBL的CD2 3 百分率的变化可作为肺炎急性期以及重症肺炎的一项监测指标。B组患儿PBL的CD2 3 百分率和血清总IgE水平同时明显增高 ,表明Ⅰ型变态反应参与了该病发病过程。故治愈后 ,还应采取早期干预措施 ,使其发展为婴幼儿哮喘的机率大大降低。
Objective To investigate the changes of CD2 3 percentage in peripheral blood lymphocytes (PBL) in children with respiratory diseases and its clinical significance. Method CD The percentage of CD2 3 of PBL in 20 children with bronchopneumonia (group A) and 9 children with severe bronchitis complicated with heart failure (group B) was measured by indirect rosette method and determined by ELISA Group B serum total IgE levels. Results Compared with the normal control group, the percentage of CD2 3 in group A increased, and the children in acute phase were higher than those in convalescent group. Serum total IgE levels in group B were also significantly higher. Conclusion 变 The percentage change of CD2 3 in PBL can be used as a monitoring indicator for the acute phase of pneumonia and severe pneumonia. The percentage of CD2 3 in PBL and the total serum IgE in group B were significantly higher at the same time, indicating that type Ⅰ allergy is involved in the pathogenesis of this disease. Therefore, after the cure, early intervention measures should be taken to greatly reduce the chances of developing asthma in infants and children.