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吸入煤尘与煤工尘肺(coal workert’s pneumoconiosis,CWP)发病之间的关系已被确认。肺泡巨噬细胞(alveolar macrophage,AM)是肺接触粉尘的前线卫士,在其发挥功能的同时很可能受到损害,从而参于CWP的发病过程。各国对煤矿粉尘细胞毒性作用的研究已日趋重视,而探讨煤尘对AM的生物学作用更为人们所关注。 AM吞噬煤尘的活跃程度煤尘进入呼吸性支气管和肺泡后,即可被AM吞噬。AM对煤尘吞噬的活跃程度,表现在细胞数量的增加和吞噬作用的强烈。Bingham等已证明,当兔分别自然吸入Utah
The relationship between inhaled coal dust and the onset of coal workert’s pneumoconiosis (CWP) has been confirmed. Alveolar macrophage (AM), a front-line defender of lung-exposed dust, is likely to be damaged while functioning, thus participating in the pathogenesis of CWP. The research on the cytotoxicity of dust in coal mines all over the world has paid more and more attention. However, it is more and more concerned to explore the biological effect of coal dust on AM. AM swallowed the activity of coal dust coal dust into the respiratory bronchial and alveoli, you can be swallowed by the AM. AM on the activity of phagocytosis of coal dust, manifested in an increase in the number of cells and phagocytosis strong. Bingham et al. Have shown that when the rabbits naturally inhaled Utah respectively