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目的观察缬沙坦治疗前、后高血压合并糖尿病患者血清脂联素的变化。方法将我院高血压合并糖尿病患者60例随机分为两组,然后分别给予缬沙坦或氨氯地平治疗至少8周,分析治疗前、后两组间的血清脂联素变化。结果与治疗前相比较,缬沙坦组血清脂联素显著降低了(P<0.01),而氨氯地平组治疗前、后的脂联素改变无显著差异性。结论与氨氯地平比较,缬沙坦在降压的同时,显著降低了血清脂联素水平。
Objective To observe the changes of serum adiponectin in patients with hypertension and before and after valsartan treatment. Methods Sixty patients with hypertension and diabetes mellitus were randomly divided into two groups, and then were given valsartan or amlodipine for at least 8 weeks respectively. The changes of serum adiponectin before and after treatment were analyzed. Results Serum adiponectin was significantly lower in valsartan group than before treatment (P <0.01), while there was no significant difference in amlodipine group before and after treatment. Conclusions Compared with amlodipine, valsartan markedly lowered serum adiponectin level while lowering blood pressure.