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目的 :观察兰索拉唑对消化性溃疡的疗效并与奥美拉唑进行比较。方法 :64例经内镜确诊的消化性溃疡病人分为 2组。兰索拉唑组 36例 (男性2 8例 ,女性 8例 ,年龄 4 1±s 8a)用兰索拉唑 30mg ,po ,qm× 4wk ;奥美拉唑组 2 8例 (男性 2 2例 ,女性 6例 ,年龄 4 2± 10a)以奥美拉唑 2 0mg ,po ,qm× 4wk。结果 :2组在溃疡愈合率 ( 89%vs90 % )、总有效率 ( 94 %vs 93% )和d 7腹痛缓解率( 97%vs 96% )均无显著差异 (P均 >0 .0 5)。但d 3腹痛缓解率兰索拉唑组显著高于奥美拉唑组 ( 83%vs 71% ,P <0 .0 5)。 2组不良反应均轻微。结论 :兰索拉唑对消化性溃疡有良好疗效
Objective: To observe the curative effect of lansoprazole on peptic ulcer and compare with omeprazole. Methods: 64 cases of endoscopic peptic ulcer patients were divided into two groups. Lansoprazole 36 patients (28 males, 8 females, age 4 1 ± s 8a) with lansoprazole 30mg, po, qm × 4wk; omeprazole group 28 (male 22 , 6 females, age 4 2 ± 10a) with omeprazole 20mg, po, qm × 4wk. Results: There was no significant difference in healing rate (89% vs 90%), total effective rate (94% vs 93%) and remission rate of d 7 (97% vs 96%) in group 2 (all P> 0.05) ). However, the rate of abdominal pain in patients with d 3 was significantly higher in the lansoprazole group than in the omeprazole group (83% vs 71%, P <0.05). 2 adverse reactions were mild. Conclusion: Lansoprazole has a good effect on peptic ulcer