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作者为确定在肾盂肾炎中,感染、肾脏疤痕和抗菌治疗间的关系,为验证“炎症反应的程度和接着发生的肾损害程度是取决于微生物侵入肾脏的速度,而不是肾内微生物的绝对数”的理论,设计了一项实验。在200克重雌大白鼠肾脏上接种075大肠杆菌3.2×10~3个,建立感染。对照组48小时后细菌增殖1000倍,而后维持在此水平。治疗组使用能使血浓度达最小抑制浓度8倍以上剂量的抗菌药物。实验结果显示。在感染导入前2.5小时至感染导入后16小时,用氨苄青霉素4天,以及在感染导入后1天,用先锋霉素Ⅰ或
To determine the relationship between pyelonephritis, infection, renal scarring and antimicrobial treatment, the authors examined the extent of the inflammatory response and the subsequent extent of renal damage depending on the rate of microbial intrusion into the kidneys, not the absolute number of intrarenal micro-organisms "Theory, designed an experiment. In 200 grams of weight female rat kidney inoculation 075 E. coli 3.2 × 10 3, the establishment of infection. After 48 hours, the control group multiplied 1000 times and then maintained at this level. The treatment group used to make the blood concentration reached a minimum inhibitory concentration of 8 times the dose of antibacterial drugs. experiment result shows. 2.5 hours prior to infection to 16 hours after infection, 4 days with ampicillin, and 1 day after infection with either cephamycin I or