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目的分析P27蛋白与腺性膀胱炎的症状严重程度、预后复发及其与膀胱癌的关联。方法应用免疫组化S-P法分别检测20例正常膀胱组织、43例腺性膀胱炎组织及25例膀胱癌组织中P27蛋白的表达程度,分别其与腺性膀胱炎的症状严重程度、预后复发及其与膀胱癌的关联。结果 P27蛋白阳性表达率在正常膀胱组织、腺性膀胱炎组织及膀胱癌组织中分别为80%,48.84%和32%,差异有统计学意义(P<0.05);在膀胱癌患者中,P27蛋白阳性者与P27蛋白阴性者术后复发率分别为12.5%和64.71%,差异有统计学意义(P<0.05)。结论 P27蛋白表达的下降或缺失,更容易诱发腺性膀胱炎及膀胱肿瘤的发生,增加膀胱癌患者术后的复发率。
Objective To analyze the severity of P27 protein and cystitis glandularis, recurrence and its association with bladder cancer. Methods The expression of P27 protein in 20 cases of normal bladder tissue, 43 cases of cystitis glandula and 25 cases of bladder cancer were detected by immunohistochemical SP method. Its association with bladder cancer. Results The positive expression rate of P27 protein in normal bladder tissue, cystitis glandula and bladder cancer tissues were 80%, 48.84% and 32%, respectively, with significant difference (P <0.05). Among bladder cancer patients, P27 The recurrence rates of positive protein and negative P27 protein were 12.5% and 64.71% respectively, the difference was statistically significant (P <0.05). Conclusions The decrease or loss of P27 protein expression is more likely to induce glandular cystitis and bladder tumor and increase the postoperative recurrence rate of bladder cancer patients.