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乳糖胺化人血清白蛋白(L-HSA)是一种人工合成的具有半乳糖残基的糖蛋白,它能选择性地通过肝细胞膜上的半乳糖受体和白蛋白受体进入肝细胞,并在溶酶体中降解。阿糖腺苷单磷酸(ara-AMP)、无环鸟苷单磷酸(ACV-MP)与L-HSA交联后能以活性形式选择性地浓集于肝脏,从而提高这两种药物抗HBV的疗效。在本研究中,作者在旱獭肝炎动物模型上,观察了这两种药物不同剂量的游离型与结合型在抗旱獭肝炎病毒(WHV)中的作用。将19只旱獭进行分组治疗:(1)单纯静注L-HSA,每日30mg/kg连续5天,4
Lactamylated human serum albumin (L-HSA) is a synthetic glycoprotein with galactose residues that selectively enters hepatocytes via the galactose receptor and albumin receptor on the liver cell membrane, And is degraded in lysosomes. Ara-AMP and ACV-MP selectively cross-linked with L-HSA in the active form to form the liver, thus enhancing the anti-HBV activity of these two drugs Efficacy. In this study, we examined the role of free and bound doses of these two drugs in the anti-Marmota hepatitis virus (WHV) on the woodchuck hepatitis animal model. Nineteen marmots were divided into groups for treatment: (1) L-HSA was injected intravenously alone for 30 consecutive days for 5 days, 4