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有研究已证实,哺乳期妇女短程口服齐多夫定(ZDV)可有效地降低母乳喂养儿童的HIV-1母婴传播。本文报道了DITRAME ANRS 049研究小组,在科特迪瓦和布基纳法索对围生期妇女使用ZDV预防15月龄母乳喂养儿童HIV-1垂直传播的疗效研究。 受试者随机接受ZDV或安慰剂(对照组)。于妊娠36～38周开始每日服用ZDV
Studies have confirmed that short-term oral zidovudine (ZDV) in lactating women is effective in reducing mother-to-child transmission of HIV-1 in breastfeeding children. This article reports on the efficacy of the DITRAME ANRS 049 Study Group on the Prevention of Vertical Transmission of HIV-1 in 15-Month-Old Breastfeeding Children in Perinatal Women in Côte d’Ivoire and in Burkina Faso. Subjects were randomized to receive either ZDV or placebo (control group). ZDV is taken daily from 36 to 38 weeks of gestation