念珠菌性阴道炎检测阳性率与末次给药时限的相关性研究

• 作 者: 叶蓉 王国萍 周薇 雄维
• 机 构: 北京大学深圳医院皮肤科,北京大学深圳医院妇产科,北京大学深圳医院检验科,
• 出 处: 中国妇幼保健
• 发表日期: 2009年20期
• 关键词: 阴道炎 白色念珠菌 检测 末次给药时限

目的:研究治疗念珠菌性阴道炎后复查病人末次给药时限对复查结果的影响及其相关性,探讨复查的最早有效时限。方法:390例首次诊断为念珠菌性阴道炎经治疗后症状好转、体征消失的复查对象,采用直接涂片法和真菌培养法检测阴道分泌物念珠菌阳性率,记录检测距末次给药的不同时限。结果:念珠菌阳性率随取标本距末次给药时间间隔的延长而下降,直接涂片法以距末次给药时限>2天后下降明显,>3天后趋于稳定,分别为60.1%、20.5%(P<0.05),两者呈负相关,相关系数r=-0.79(P<0.05)。真菌培养法检测白色念珠菌阳性率差异无显著性(P>0.05)。结论:复查距末次给药不同时间对白带涂片法复查结果影响较大,停药4天后取样结果趋于稳定。真菌培养法则对结果影响较小。

Objective: To study the effect and the correlation of the last administration period of patients after Candida vaginitis on the review results and to discuss the earliest effective time limit of the review. Methods: 390 cases of the first diagnosis of Candida vaginitis after treatment, the symptoms improved, the disappearance of the signs of the object, the direct smear and fungal culture of Candida vaginal secretions positive rate detection record from the last administration of different time limit. Results: The positive rate of Candida decreased with the prolongation of the last administration interval. The direct smear method decreased significantly from> 2 days after the last administration and was stable after> 3 days, which were respectively 60.1% and 20.5% (P <0.05). There was a negative correlation between them (r = -0.79, P <0.05). There was no significant difference in the positive rate of Candida albicans detected by fungal culture (P> 0.05). Conclusions: The results of the double-dosing test showed that the results of the leucorrhea smear test were significantly different from the last dosing time. The results of the sampling tended to be stable after 4 days of withdrawal. Fungus law has little effect on the results.