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以乙酰乙酸乙酯为起始原料,以氯乙酰基为氨基保护基经六步反应合成了2-(2-氯乙酰氨基噻唑-4)-(Z)-2甲氧亚胺乙酸。其顺式异构体的总收率达42.56％,该化合物为制备氨噻肟唑头孢菌素和类似头孢菌素的重要中间原料。
Using ethyl acetoacetate as the starting material and 2- (2-chloroacetamidothiazole-4) - (Z) -2methoxyiminoacetic acid was synthesized via a six-step reaction using chloroacetyl as the amino protecting group. The total yield of its cis-isomer was 42.56%. This compound is an important intermediate for preparing cefotaxime and cephalosporins.