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目的 探讨缺氧对系统性硬皮病 (SSc)患者皮肤硬化的影响。方法 测定 SSc患者血氧分压和皮肤硬度积分，对二者进行直线相关分析，并测定低氧 (2.5％氧浓度 )对体外培养的 SSc患者皮肤成纤维细胞增殖的影响。结果 30例 SSc患者血氧分压为 6.38～ 12.06 kPa，平均 (9.53± 1.93)kPa； 20例正常对照组为 (10.67～ 13.33)kPa，平均为 (12.01± 0.81)kPa。前者比后者显著降低 (t=5.276,P
Objective To investigate the effect of hypoxia on skin sclerosis in patients with systemic scleroderma (SSc). Methods The blood pressure and skin hardness scores of SSc patients were determined. The correlation between the two groups was analyzed by linear correlation. The effects of hypoxia (2.5% oxygen) on the proliferation of skin fibroblasts in vitro were determined. Results The partial pressure of oxygen in 30 patients with SSc was 6.38 ~ 12.06 kPa, with an average of (9.53 ± 1.93) kPa. The average plasma concentration of 20 patients was (10.67 ~ 13.33) kPa, with an average of (12.01 ± 0.81) kPa. The former was significantly lower than the latter (t = 5.276, P