论文部分内容阅读
目的观察高血压患者脑出血后血肿清洗液中细胞因子含量变化及其意义。方法采用双抗体夹心法ELISA对54例高血压脑出血患者的血肿清洗液分别在发病后第1、3、5、7天进行连续检测,并与30例健康成人的结果对照。结果高血压患者脑出血血肿清洗液白细胞介素(IL-8、IL-6)、超敏C反应蛋白(hsCRP)及神经元特异性烯醇化酶(NSE)含量在4个时间点均高于对照组(P<0.05)。在病程的第3天血肿清洗液IL-8、IL-6、hsCRP及NSE含量明显高于第1天(P<0.05)。结论高血压脑出血患者血肿清洗液IL-8、IL-6、hsCRP及NSE明显升高,可能与疾病的转归有关。
Objective To observe the changes of cytokines in hematoma washing fluid after intracerebral hemorrhage in hypertensive patients and its significance. Methods 54 patients with hypertensive intracerebral hemorrhage were detected by double antibody sandwich ELISA on the 1st, 3rd, 5th and 7th day after the onset of disease, respectively. The results were compared with those of 30 healthy adults. Results The levels of interleukin (IL-8), hsCRP and NSE in patients with hypertensive cerebral hemorrhage were higher than those at 4 time points Control group (P <0.05). The levels of IL-8, IL-6, hsCRP and NSE in hematoma washing fluid on the third day of the course were significantly higher than those on the first day (P <0.05). Conclusion The levels of IL-8, IL-6, hsCRP and NSE in hematoma were significantly higher in patients with hypertensive intracerebral hemorrhage, which may be related to the prognosis of the disease.