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We demonstrate nonlinear pulse compression of an 8 kHz Nd∶YVO4 picosecond laser using the multi-pass-cell[MPC]tech-nique with fused silica as the nonlinear medium.The pulse duration is compressed from 12.5 ps to 601 fs,corresponding to a pulse shortening factor of 20.8.The output pulse energy is 154 μJ with an efficiency of 74.5％.To the best of our knowledge,this is the highest pulse compression ratio achieved in a single-stage MPC with bulk material as the nonlinear medium.The laser power stability and the beam quality[M2]before and after the MPC are also experimentally studied.Both the laser power stability and the beam quality are barely deteriorated by the MPC device.