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【问】失代偿期肝硬变为什么易发生自发性细菌性腹膜炎(SBP)? 【答】失代偿期肝硬变本来预后不佳,一旦并发SBP,预后极其凶险,可导致中毒性休克,诱发肝昏迷、肝肾综合征,病死串高达85%～95%,是肝硬变死亡的主要原因之一。失代偿期肝硬变井SBP与下列因素有关: 1.肝硬变患者的肠道菌群分布与正常人不同,其回肠、空肠,甚至十二指肠均有大肠杆菌类细菌繁殖;加之肝硬变时肝脏结缔组织增生,破坏正常的肝结构,导致门静脉高压,使肠道血液回流受阻,肠壁郁血、水肿,从而使正常粘膜屏障功能
Q: Why is decompensable cirrhosis prone to spontaneous bacterial peritonitis (SBP)? [A] decompensated cirrhosis has a poor prognosis, once complicated by SBP, the prognosis is extremely dangerous, can lead to toxic shock , Induced hepatic coma, liver and kidney syndrome, died of string up to 85% to 95%, is one of the major causes of death from cirrhosis. SBP with decompensated liver cirrhosis and the following factors: 1. The distribution of intestinal flora in patients with cirrhosis is different from normal, the ileum, jejunum, and duodenum have Escherichia coli bacteria; in addition Liver cirrhosis of connective tissue hyperplasia, destruction of normal liver structure, leading to portal hypertension, obstruction of intestinal blood backflow, bowel depression, edema, so that the normal mucosal barrier function