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目的 探讨激光周边虹膜切除术后残余性闭角型青光眼的药物治疗效果。方法 对激光周边虹膜切除术后残余性闭角型青光眼患者 6 8例 (6 8只眼 )进行前瞻性临床对照研究。试验组应用 0 0 0 5 %拉坦前列素滴眼液每日滴眼 1次 ,对照组应用 0 5 %噻吗心安滴眼液每日滴眼 2次。随访 6个月 ,观察和比较两种药物治疗前、后患者的眼压、视力、视野及视乳头杯 /盘比值变化。结果 6 8例中 ,有 5 6例 (82 4 % )完成 6个月随访。两组患者治疗前的基础眼压值比较 ,差异无显著意义(t=0 2 36 ,P =0 814 ) ;治疗后 3d ,各组眼压值与治疗前比较 ,差异均有显著意义 (两组间比较F =2 87 4 4 1,P <0 0 0 1,拉坦前列素组t=14 10 3,P <0 0 0 1;噻吗心安组t=10 30 8,P <0 0 0 1) ;各组随访患者药物治疗前、后眼压值比较 ,差异均有显著意义 (两组间比较F =74 2 5 9,P <0 0 0 1;拉坦前列素组F =14 8 787,P <0 0 0 1;噻吗心安组F =5 4 875 ,P <0 0 0 1)。治疗后两组间各个随访时间点的眼压值比较 ,差异均有显著意义 (t值分别为 - 6 12 7,- 5 930 ,- 6 2 0 1,- 5 931,- 7 4 12 ,- 6 6 4 0 ,- 6 75 6 ;均P <0 0 0 1) ;各组用药后不同随访时间点的眼压值与用药前比较 ,差异均有显著意义 (平均差异值 ,拉坦前列
Objective To investigate the therapeutic effect of residual angle-closure glaucoma after laser iridotomy. Methods Sixty-eight patients (68 eyes) with residual angle-closure glaucoma after laser iridotomy were prospectively controlled. The test group was treated with 100% latanoprost eye drops once a day, while the control group was treated with 0% timolol eye drops twice a day. The patients were followed up for 6 months. The changes of intraocular pressure, visual acuity, visual field and optic cup / disk ratio before and after treatment were observed and compared. Results Of 68 cases, 56 cases (82 4%) completed 6 months follow-up. There was no significant difference between the two groups before treatment (t = 0 2 36, P = 0 814); after 3 days of treatment, the intraocular pressure values in each group were significantly different from those before treatment (two The difference between groups was F = 2 87 4 4 1, P <0 0 0 1, latanoprost group t = 14 10 3, P <0 0 0 1; timolol group t = 10 30 8, P 0 0 0 0 1). The intraocular pressure (IOP) values before and after drug treatment in each group were significantly different (F = 74 2 59, P 0 01; latanoprost F 14 8 787, P <0 0 0 1; and timolol group F = 5 4 875, P <0 0 0 1). After treatment, the intraocular pressure at each time point after treatment showed significant difference (t = -6,127, -5,930, -6,201, -5,931, -7,412, - (P <0.01). There were significant differences in intraocular pressure (IOP) between the two groups at different time points after treatment