真菌性脑膜炎继发癫临床研究

• 作 者: 杨柳 张敏 贺曦
• 机 构: 重庆市急救医疗中心神经内科,
• 出 处: 中国现代神经疾病杂志
• 发表日期: 2015年02期
• 关键词: 真菌性脑膜炎 发癫 脑膜炎 真菌性 脑脊髓液 磁共振成像 脑电图 脑电描记术 额颞叶 患者脑脊液 脑膜炎

对10例真菌性脑膜炎继发癫患者的临床表现,以及脑脊液、影像学和脑电图特点进行回顾分析,提示真菌性脑膜炎累及大脑皮质者易继发癫,尤其是影像学检查发现额颞叶病灶、脑电图呈中至重度异常的患者更易诱发癫发作。真菌性脑膜炎患者脑脊液内毒素和(1-3)-β-D葡聚糖水平均升高,是否与继发癫相关尚待进一步观察。

The clinical manifestations of 10 patients with epilepsy secondary to fungal meningitis and the features of cerebrospinal fluid, radiology and electroencephalography were retrospectively analyzed. It is suggested that fungal meningitis is associated with epilepsy in the cerebral cortex, especially the imaging examination Found in the frontotemporal lobe lesions, EEG showed moderate to severe abnormalities more likely to induce epileptic seizures. Cerebrospinal fluid endotoxin and (1-3) -β-D-glucan levels in patients with fungal meningitis are elevated, and whether or not they are associated with secondary epilepsy remains to be seen.