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[目的]观察D-二聚体测定在结肠癌中的临床意义。[方法]62例接受治疗的结肠癌患者为观察组,以同期体检的健康人群为对照组;观察2组患者D-二聚体阳性率,观察组中发生转移及未发生转移患者化疗前的D-二聚体测定结果比较、化疗前后D-二聚体变化与疗效之间的关系、临床分期与D-二聚体含量之间的关系。[结果]观察组D-二聚体检查阳性率为46.77%,对照组为0%,观察组患者D-二聚体检查阳性率明显高于对照组(P<0.05)。观察组中未发生转移、发生周围淋巴结转移、发生远处脏器转移患者D-二聚体含量分别为(0.23±0.09)mg/L、(1.51±1.45)mg/L、(2.23±1.29)mg/L,三者之间比较差异有统计学意义(P<0.05);结肠癌Ⅱ期、Ⅲ期、Ⅳ期D-二聚体含量分别为(0.27±0.08)mg/L、(1.16±0.36)mg/L、(2.01±0.82)mg/L,各分期D-二聚体含量比较差异有统计学意义(P<0.05)。观察组化疗后完全缓解+部分缓解患者D-二聚体变化值为(-0.43±0.21)mg/L,较治疗前显著性下降(P<0.05);病变稳定患者为(0.08±0.09)mg/L,与治疗前无明显改变(P>0.05);病变进展患者为(0.92±0.34)mg/L,较治疗前显著升高(P<0.05)。[结论]D-二聚体含量与结肠癌发病情况、是否发生转移及转移情况、疾病临床分期、预后等有着密切的联系,应灵活运用并掌握该项检查。
[Objective] To observe the clinical significance of D-dimer in colon cancer. [Methods] Sixty-two patients with colorectal cancer who underwent treatment were selected as the observation group, and healthy people in the same period were taken as the control group. The positive rate of D-dimer in the two groups was observed. Before the chemotherapy, the patients with metastasis and no metastasis in the observation group D-dimer assay results, before and after chemotherapy D-dimer changes and the relationship between efficacy, clinical stage and the relationship between D-dimer content. [Results] The positive rate of D-dimer in observation group was 46.77%, while that in control group was 0%. The positive rate of D-dimer in observation group was significantly higher than that in control group (P <0.05). The D-dimer levels in the observation group were (0.23 ± 0.09) mg / L, (1.51 ± 1.45) mg / L, (2.23 ± 1.29), respectively) without metastasis and peripheral lymph node metastasis. (P <0.05). The contents of D-dimer in stages Ⅱ, Ⅲ and Ⅳ of colon cancer were (0.27 ± 0.08) mg / L and (1.16 ± 0.36) mg / L and (2.01 ± 0.82) mg / L, respectively. There was significant difference in the content of D-dimer in each stage (P <0.05). The change of D-dimer in complete remission + partial remission group was (-0.43 ± 0.21) mg / L in the observation group, which was significantly lower than that before treatment (P <0.05). The stable lesion was (0.08 ± 0.09) mg / L, with no significant change before treatment (P> 0.05). The progression of the disease was (0.92 ± 0.34) mg / L, which was significantly higher than that before treatment (P <0.05). [Conclusion] The content of D-dimer is closely related to the incidence of colon cancer, metastasis and metastasis, clinical stage and prognosis of colon cancer. It should be flexibly used and mastered.