Effect of thienorphine on intestinal transit and isolated guinea-pig ileum contraction

• 作 者: Pei-Lan Zhou Yu-Lei Li Ling-Di
• 机 构: BeijingInstituteofPharmacologyandToxicology
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2013年9期
• 关键词: Thienorphine BUPRENORPHINE GUINEA-PIG ILEUM GUT TRANSIT CONTRACTION Thienorphine
• 基金项目: Supported by National New Drugs Foundation of China, No.2011ZX09101-005-01,“Integrated Drug Discovery Technology Plat form” of National Science and Technology Major Projects for “Major New Drugs Innov

AIM: To evaluate the effect of thienorphine on small intestinal transit in vivo and on guinea-pig ileum (GPI) contraction in vitro . METHODS: The effects of thienorphine on intestinal transit were examined in mice and in isolated GPI. Buprenorphine and mo