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目的观察苯扎氯铵(BZK)避孕凝胶剂的避孕效果。方法将240例健康育龄期女性志愿者随机分为两组,其中120例使用BZK避孕凝胶剂(BZK组),120例使用壬苯醇醚(NP-9)避孕胶冻剂(NP-9组),随访6个月,以寿命表法、log-rank检验比较两组的妊娠率、因症停用率和非医学原因停用率。结果两组妇女6个月时的随访率,BZK组和NP-9组分别为100·0%(120/120)和99·2%(119/120);粗累积妊娠率分别为1·72/100妇女和0·91/100妇女;粗累积因症停用率为0和2·68/100妇女;粗累积非医学原因停用率为3·39/100妇女和6·05/100妇女;两组的3种粗累积率分别比较,差异均无统计学意义(P>0·05)。结论BZK避孕凝胶剂的避孕作用与NP-9避孕胶冻剂同样有效。
Objective To observe the contraceptive effect of BZK contraceptive gel. Methods A total of 240 healthy women of childbearing age were randomly divided into two groups: 120 cases received BZK contraceptive gel (BZK group) and 120 cases received NP-9 contraceptive gel (NP-9) Group) were followed up for 6 months. The pregnancy rate, morbidity disability rate and non-medical disabling rate were compared by log-rank test using life table method. Results The follow-up rates at 6 months in both groups were 100.0% (120/120) and 99.2% (119/120) in BZK group and NP-9 group respectively. The cumulative cumulative pregnancy rates were 1.72 / 100 women and 0.91 / 100 women; the crude accumulation rate was 0 and 2.68 / 100 women; and the cumulative non-medical reasons were 3.39 / 100 women and 6.05 / 100 women There was no significant difference in the three kinds of crude accumulation rates between the two groups (P> 0.05). Conclusion The contraceptive effect of BZK contraceptive gel is as effective as NP-9 contraceptive.