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目的分析肝癌患者血浆中载脂蛋白M(apoM)的水平,阐明apoM与其他脂蛋白或载脂蛋白的关系。方法应用dot-blotting技术检测36例肝癌患者及64名健康人血浆中apoM的水平,酶法及比浊法检测肝癌患者血浆中TG、TC、apoAI、apoB、Lp(a)、HDL-C、LDL-C;比较原发性肝细胞癌患者和健康人血浆中apoM的水平,并对apoM与其他脂蛋白的关系进行相关性分析。结果血浆apoM水平肝癌组(712.87±345.98)INT/mm2明显高于健康人组(433.70±79.53)INT/mm2(t=3.399,P<0.05),差异具有统计学意义。肝癌患者血浆中的TG、HDL-C、apoAⅠ和Lp(a)水平明显低于健康人,而TC、apoB和LDL-C水平与健康人差异无统计学意义(P>0.05)。以Pearson相关分析法检测健康人组血浆apoM与Lp(a)呈正相关(r=0.6275,P=0.0005),与HDL-C呈负相关(r=-0.4587,P=0.0161),与其他血脂成分无明显的相关性。肝癌患者血浆apoM与血脂参数无相关性。结论肝癌患者血浆apoM水平明显高于健康人,apoM分析有可能作为判断肝癌受损程度的一种辅助指标。
Objective To analyze the plasma levels of apolipoprotein M (apoM) in patients with hepatocellular carcinoma and to elucidate the relationship between apoM and other lipoproteins or apolipoproteins. Methods The levels of apoM in plasma from 36 HCC patients and 64 healthy individuals were detected by dot-blotting. The levels of TG, TC, apoAI, apoB, Lp (a), HDL-C, LDL-C. The plasma levels of apoM in patients with primary hepatocellular carcinoma and healthy subjects were compared. The correlation between apoM and other lipoproteins was also analyzed. Results The plasma level of apoM in hepatocellular carcinoma (712.87 ± 345.98) INT / mm2 was significantly higher than that in healthy subjects (433.70 ± 79.53) INT / mm2 (t = 3.399, P <0.05). The levels of TG, HDL-C, apoAⅠ and Lp (a) in plasma of patients with liver cancer were significantly lower than those in healthy people, while the levels of TC, apoB and LDL-C were not statistically different from those in healthy people (P> 0.05). Pearson correlation analysis showed that plasma apoM was positively correlated with Lp (a) (r = 0.6275, P = 0.0005) and negatively correlated with HDL-C (r = -0.4587, P = 0.0161) No obvious correlation. There was no correlation between apoM and lipid parameters in patients with liver cancer. Conclusions Plasma apoM level in patients with liver cancer is significantly higher than that in healthy people. ApoM analysis may be used as a supplementary indicator to determine the degree of liver cancer damage.