ICAM-1E469K基因多态性是自发性颈动脉夹层的一个危险因素

• 作 者: Longoni M. Grond-Ginsbach C. Grau A.J. 李青波
• 机 构: Department of Neurology HS Gerardo via Donizetti 106 20052 Monza Italy Dr.,
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年09期
• 关键词: 颈动脉夹层 基因多态性 细胞间黏附分子 基因类型 遗传倾向 炎症反应 基因遗传 基因型 变异体 亚群

In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.

In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p <0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.