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目的:评价氯吡格雷与阿司匹林联用对冠心病心绞痛患者的疗效及其对血清IL-6、hs-CRP水平的影响。方法:选取2014年9月—2017年2月间收治的冠心病患者伴心绞痛患者90例临床资料,采用随机数表法将其分为对照组和观察组,每组45例;对照组患者给予阿司匹林肠溶片口服治疗,观察组患者在对照组基础上加用盐酸氯吡格雷片治疗,比较两组患者治疗后的总有效率以及治疗前后白介素-6(IL-6)、超敏C反应蛋白(Hs-CRP)等炎症指标及纤维蛋白原(Fib)、D-二聚体(D-D)等血液流变学指标的改善情况。结果:观察组患者治疗后IL-6、Hs-CRP等炎症指标测得值低于对照组(P<0.05),Fib、D-D测得值低于对照组(P<0.05),总有效率为93.33%高于对照组为75.56%,心电图疗效的总有效率95.56%高于对照组为71.11%(P<0.05)。结论:氯吡格雷与阿司匹林用于治疗冠心病伴心绞痛患者疗效较显著,可有效改善其各炎症因子水平,纠正高凝血状态。
Objective: To evaluate the effect of clopidogrel combined with aspirin on patients with coronary heart disease and its effect on serum IL-6, hs-CRP levels. Methods: The clinical data of 90 patients with angina pectoris who were admitted to our hospital from September 2014 to February 2017 were selected and divided into control group and observation group (n = 45) by random number table method. Patients in control group Aspirin enteric-coated tablets oral treatment, the observation group patients in the control group plus clopidogrel hydrochloride tablets treatment, the two groups were compared the total effective rate after treatment and before and after treatment of interleukin-6 (IL-6), hypersensitivity C reaction (Hs-CRP) and other indicators of inflammation and fibrinogen (Fib), D-dimer (DD) and other indicators of the improvement of hemorheology. Results: The levels of IL-6 and Hs-CRP in the observation group were lower than those in the control group (P <0.05), but the values of Fib and DD in the observation group were lower than those in the control group (P <0.05) 93.33% higher than the control group was 75.56%. The total effective rate of ECG was 95.56% higher than that of the control group (71.11%, P <0.05). Conclusion: Clopidogrel and aspirin are effective in treating patients with coronary heart disease and angina pectoris. They can effectively improve the levels of each inflammatory factor and correct hypercoagulable state.